Progress and challenges in the discovery of macrofilaricidal drugs.
Identifieur interne : 004C20 ( Main/Exploration ); précédent : 004C19; suivant : 004C21Progress and challenges in the discovery of macrofilaricidal drugs.
Auteurs : Timothy G. Geary [Canada] ; Charles D. MackenzieSource :
- Expert review of anti-infective therapy [ 1744-8336 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Brugia (), Composés macrocycliques (usage thérapeutique), Doxycycline (usage thérapeutique), Découverte de médicament, Filaricides (pharmacologie), Filaricides (usage thérapeutique), Filariose lymphatique (parasitologie), Filariose lymphatique (traitement médicamenteux), Humains, Lactones (usage thérapeutique), Macrolides (usage thérapeutique), Microfilaria (), Onchocerca (), Onchocercose (parasitologie), Onchocercose (traitement médicamenteux), Wuchereria bancrofti ().
- MESH :
- parasitologie : Filariose lymphatique, Onchocercose.
- pharmacologie : Filaricides.
- traitement médicamenteux : Filariose lymphatique, Onchocercose.
- usage thérapeutique : Composés macrocycliques, Doxycycline, Filaricides, Lactones, Macrolides.
- Animaux, Brugia, Découverte de médicament, Humains, Microfilaria, Onchocerca, Wuchereria bancrofti.
English descriptors
- KwdEn :
- Animals, Brugia (drug effects), Doxycycline (therapeutic use), Drug Discovery, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (parasitology), Filaricides (pharmacology), Filaricides (therapeutic use), Humans, Lactones (therapeutic use), Macrocyclic Compounds (therapeutic use), Macrolides (therapeutic use), Microfilariae (drug effects), Onchocerca (drug effects), Onchocerciasis (drug therapy), Onchocerciasis (parasitology), Wuchereria bancrofti (drug effects).
- MESH :
- chemical , pharmacology : Filaricides.
- chemical , therapeutic use : Doxycycline, Filaricides, Lactones, Macrocyclic Compounds, Macrolides.
- drug effects : Brugia, Microfilariae, Onchocerca, Wuchereria bancrofti.
- drug therapy : Elephantiasis, Filarial, Onchocerciasis.
- parasitology : Elephantiasis, Filarial, Onchocerciasis.
- Animals, Drug Discovery, Humans.
Abstract
Control of human filarial infections currently depends on chemotherapeutic strategies predominantly directed at microfilariae. Doxycycline therapy in an extended daily dose regimen sterilizes and kills adult stages, but the utility of this drug for routine field use remains an issue of concern. No macrofilaricidal drugs with efficacy after one or two doses are available for use, delaying the achievement of the elimination or eradication of onchocerciasis and lymphatic filariasis. Moxidectin, a macrocyclic lactone, is currently in clinical trials for onchocerciasis. A few other drugs that have already been approved for use in veterinary practice or in human medicine for other indications are available for investigation. Early drug discovery pipelines are poorly populated and the process of macrofilaricide discovery and development remains highly challenging. In particular, the lack of convenient, validated animal models in an antifilarial drug discovery pathway is an unresolved issue.
DOI: 10.1586/eri.11.76
PubMed: 21819332
Affiliations:
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Geary</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Parasitology, McGill University, 21111 Lakeshore Road, Ste-Anne-de-Bellevue QC, H9X 3V9, Canada. timothy.g.geary@mcgill.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institute of Parasitology, McGill University, 21111 Lakeshore Road, Ste-Anne-de-Bellevue QC, H9X 3V9</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Mackenzie, Charles D" sort="Mackenzie, Charles D" uniqKey="Mackenzie C" first="Charles D" last="Mackenzie">Charles D. 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Doxycycline therapy in an extended daily dose regimen sterilizes and kills adult stages, but the utility of this drug for routine field use remains an issue of concern. No macrofilaricidal drugs with efficacy after one or two doses are available for use, delaying the achievement of the elimination or eradication of onchocerciasis and lymphatic filariasis. Moxidectin, a macrocyclic lactone, is currently in clinical trials for onchocerciasis. A few other drugs that have already been approved for use in veterinary practice or in human medicine for other indications are available for investigation. Early drug discovery pipelines are poorly populated and the process of macrofilaricide discovery and development remains highly challenging. In particular, the lack of convenient, validated animal models in an antifilarial drug discovery pathway is an unresolved issue.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><noCountry><name sortKey="Mackenzie, Charles D" sort="Mackenzie, Charles D" uniqKey="Mackenzie C" first="Charles D" last="Mackenzie">Charles D. Mackenzie</name></noCountry><country name="Canada"><region name="Québec"><name sortKey="Geary, Timothy G" sort="Geary, Timothy G" uniqKey="Geary T" first="Timothy G" last="Geary">Timothy G. Geary</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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